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Emerging roles of podoplanin in vascular development and homeostasis

Yanfang Pan,Lijun Xia

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 421-430 doi: 10.1007/s11684-015-0424-9

Abstract: This review provides a comprehensive overview of the roles of PDPN in vascular development and lymphoidorgan maintenance and discusses the mechanisms that regulate PDPN expression related to its function

Keywords： podoplanin     CLEC-2     Prox1     O-glycosylation     lymphatic vascular development and maintenance     lymphoidorgan homeostasis    

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Paradoxical role of Id proteins in regulating tumorigenic potential of lymphoid cells

Sumedha Roy, Yuan Zhuang

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 374-386 doi: 10.1007/s11684-018-0652-x

Abstract:

A family of transcription factors known as Id proteins, or inhibitor of DNA binding and differentiation, is capable of regulating cell proliferation, survival and differentiation, and is often upregulated in multiple types of tumors. Due to their ability to promote self-renewal, Id proteins have been considered as oncogenes, and potential therapeutic targets in cancer models. On the contrary, certain Id proteins are reported to act as tumor suppressors in the development of Burkitt’s lymphoma in humans, and hepatosplenic and innate-like T cell lymphomas in mice. The contexts and mechanisms by which Id proteins can serve in such contradictory roles to determine tumor outcomes are still not well understood. In this review, we explore the roles of Id proteins in lymphocyte development and tumorigenesis, particularly with respect to inhibition of their canonical DNA binding partners known as E proteins. Transcriptional regulation by E proteins, and their antagonism by Id proteins, act as gatekeepers to ensure appropriate lymphocyte development at key checkpoints. We re-examine the derailment of these regulatory mechanisms in lymphocytes that facilitate tumor development. These mechanistic insights can allow better appreciation of the context-dependent roles of Id proteins in cancers and improve considerations for therapy.

Keywords： Id proteins     lymphoma     leukemia     T cells     B cells     tumor suppressor     oncogene    

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Clinical characteristics and prognostic factors of patients with mature T-cell lymphoid malignancies:

Wen Xue,Yan Sheng,Xiangqin Weng,Yongmei Zhu,Yan Zhao,Pengpeng Xu,Xiaochun Fei,Xiaoyan Chen,Li Wang,Weili Zhao

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 468-477 doi: 10.1007/s11684-015-0419-6

Abstract:

Mature T-cell lymphoid malignancies comprise a group of heterogeneous diseases that vary in clinicopathologicalBone marrow (BM) infiltration is more commonly present in mature T-cell lymphoid malignancies comparedstudy, clinical characteristics and prognostic factors were analyzed in 225 patients with mature T-cell lymphoidclinical characteristics may be useful in more effectively stratifying patients with mature T-cell lymphoid

Keywords： mature T-cell lymphoid malignancies     clonal T-cell population     bone marrow infiltration     prognostic factors    

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post-transplantation cyclophosphamide for allogeneic peripheral stem cell transplantation for adult patients with lymphoid

Ling Wang, Lining Wang, Xing Fan, Wei Tang, Jiong Hu

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 108-115 doi: 10.1007/s11684-019-0730-8

Abstract: Improved survival rate was reported in lymphoid malignancies following PT-Cy strategy compared with myeloidprophylaxis after myeloablative conditioning and T cell-replete peripheral stem cell transplantation in lymphoidA prospective study with additional patients is warranted to confirm the role of PT-Cy in lymphoid malignancy

Keywords： post-transplantation cyclophosphamide     allogeneic hematopoietic stem cell transplantation     lymphoid malignancies    

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Zfyve16 regulates the proliferation of B-lymphoid cells

Xuemei Zhao, Donghe Li, Qingsong Qiu, Bo Jiao, Ruihong Zhang, Ping Liu, Ruibao Ren

Frontiers of Medicine 2018, Volume 12, Issue 5,   Pages 559-565 doi: 10.1007/s11684-017-0562-3

Abstract: The proliferation potential of Zfyve16KO B-lymphoid cells also significantlyproliferation of T cells, possibly through the TGF-β signaling, but upregulates the proliferation of B-lymphoid

Keywords： Zfyve16     endofin     hematopoiesis     TGF-β     lymphocytes    

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Engineered Vasculature for Organ-on-a-Chip Systems Review

Abdellah Aazmi, Hongzhao Zhou, Yuting Li, Mengfei Yu, Xiaobin Xu, Yutong Wu, Liang Ma, Bin Zhang, Huayong Yang

Engineering 2022, Volume 9, Issue 2,   Pages 131-147 doi: 10.1016/j.eng.2021.06.020

Abstract:

Organ-on-a-chip technology, a promising three-dimensional (3D) dynamic culture method, ensures accurateThe circulatory system, the most abundant organ in the human body, plays a crucial role in oxygen exchangeThus, it is essential to integrate the circulatory system into an organ-on-a-chip to recreate tissueand organ microenvironments and physiological functions.This review discusses the synergy between the vasculature and the emerging organ-on-a-chip technology

Keywords： Organ-on-a-chip     Vasculature     Bioprinting     Tumor-on-a-chip    

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A literature review of perishable medical resource management

Frontiers of Engineering Management   Pages 710-726 doi: 10.1007/s42524-023-0278-9

Abstract: In recent decades, healthcare providers have faced mounting pressure to effectively manage highly perishable and limited medical resources. This article offers a comprehensive review of supply chain management pertaining to such resources, which include transplantable organs and healthcare products. The review encompasses 93 publications from 1990 to 2022, illustrating a discernible upward trajectory in annual publications. The surveyed literature is categorized into three levels: Strategic, tactical, and operational. Key problem attributes and methodologies are analyzed through the assessment of pertinent publications for each problem level. Furthermore, research on service innovation, decision analytics, and supply chain resilience elucidates potential areas for future research.

Keywords： perishable medical resources     organ transplant     healthcare products     decision analytics     operations management    

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Piezoelectric pump with flexible venous valves for active cell transmission

Frontiers of Mechanical Engineering 2022, Volume 17, Issue 4, doi: 10.1007/s11465-022-0712-4

Abstract: The development of organ-on-a-chip systems demands high requirements for adequate micro-pump performanceThe proposed pump can help to construct the circulating organ-on-a-chip system, and the simple structuredesign of the micro-pump and providing a reference for the further study of active cell transport in organ-on-a-chip

Keywords： venous valve     flexible venous valve     cell transmission     organ-on-a-chip system     piezoelectric device    

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Review on the 3D Printing of Functional Structures for Medical Phantoms and Regenerated Tissue and Organ

Kan Wang, Chia-Che Ho, Chuck Zhang, Ben Wang

Engineering 2017, Volume 3, Issue 5,   Pages 653-662 doi: 10.1016/J.ENG.2017.05.013

Abstract: emulate the geometric structures of human organs, but also possess the properties and functions of the organ

Keywords： 3D printing     3D bioprinting     Medical phantom     Regenerated tissue/organ     Scaffold    

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A novel intravenous general anesthetic--- emulsified isoflurane: from bench to bedside

Cheng Zhou, Jin Liu

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 381-387 doi: 10.1007/s11684-012-0229-z

Abstract: utility has spread from intravenous general anesthesia to various fields including regional anesthesia, organ

Keywords： emulsified isoflurane (EI)     general anesthesia     regional anesthesia     organ protection     anesthetic pharmacological    

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State-of-the-art of intelligent minimally invasive surgical robots

Masakatsu G. Fujie, Bo Zhang

Frontiers of Medicine 2020, Volume 14, Issue 4,   Pages 404-416 doi: 10.1007/s11684-020-0743-3

Abstract: A number of developed countries are rapidly turning into super-aged societies. Consequently, the demand for reduced surgical invasiveness and enhanced efficiency in the medical field has increased due to the need to reduce the physical burden on older patients and shorten their recovery period. Intelligent surgical robot systems offer high precision, high safety, and reduced invasiveness. This paper presents a review of current intelligent surgical robot systems. The history of robots and three types of intelligent surgical robots are discussed. The problems with current surgical robot systems are then analyzed. Several aspects that should be considered in designing new surgical systems are discussed in detail. The paper ends with a summary of the work and a discussion of future prospects for surgical robot development.

Keywords： robot history     medical robot     surgical robot     radiofrequency ablation     organ model    

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Organ function support in patients with coronavirus disease 2019: Tongji experience

Yong Li, Fan He, Ning Zhou, Jia Wei, Zeyang Ding, Luyun Wang, Peng Chen, Shuiming Guo, Binhao Zhang, Xiaoning Wan, Wei Zhu, on behalf of Multidisciplinary Team for COVID-19, Optical Valley Branch of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 232-248 doi: 10.1007/s11684-020-0774-9

Abstract: COVID-19 can cause multiple organ dysfunction, such as respiratory and circulatory failure, liver andGiven the lack of specific antiviral drugs, multi-organ function support treatment is important for patientsmortality of patients with severe- and critical-type COVID-19, this paper summarizes the experience of organ

Keywords： COVID-19     severe and critical type     organ function support    

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Determining “abnormal” levator hiatus distensibility using three-dimensional transperineal ultrasound in Chinese women

Chaoran Dou, Qin Li, Tao Ying, Yulin Yan, Xia Wang, Bing Hu

Frontiers of Medicine 2018, Volume 12, Issue 5,   Pages 572-579 doi: 10.1007/s11684-017-0561-4

Abstract:

The dimension of the levator hiatus is a possible predictor of pelvic organ prolapse (POP).

Keywords： three-dimensional transperineal ultrasound     levator hiatus     levator ani muscle     pelvic organ prolapse    

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Legacies and health risks of heavy metals, polybrominated diphenyl ethers, and polychlorinated dibenzo-dioxins/furans at e-waste recycling sites in South China

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 7, doi: 10.1007/s11783-023-1679-z

Abstract:

● Heavy metals and organic toxins may persist in legacy sites for a long time.

Keywords： E-waste     Human health risk     Organ risk     Heavy metal toxicity     PBDE     PCDD/F    

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Tissue Engineering： Leading Edge of Modern Bio-life Science

Zhang Disheng

Strategic Study of CAE 2000, Volume 2, Issue 10,   Pages 21-25

Abstract: scientific field to study and develop biologic substitutes for repairing tissue defects and restoring organhistorical development of tissue engineering, the status of researches in different kinds of tissue and organ

Keywords： tissue engineering     degradable material     reconstruction of tissue and organ     seed cell    

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Title Author Date Type Operation

Emerging roles of podoplanin in vascular development and homeostasis

Yanfang Pan,Lijun Xia

Journal Article

Paradoxical role of Id proteins in regulating tumorigenic potential of lymphoid cells

Sumedha Roy, Yuan Zhuang

Journal Article

Clinical characteristics and prognostic factors of patients with mature T-cell lymphoid malignancies:

Wen Xue,Yan Sheng,Xiangqin Weng,Yongmei Zhu,Yan Zhao,Pengpeng Xu,Xiaochun Fei,Xiaoyan Chen,Li Wang,Weili Zhao

Journal Article

post-transplantation cyclophosphamide for allogeneic peripheral stem cell transplantation for adult patients with lymphoid

Ling Wang, Lining Wang, Xing Fan, Wei Tang, Jiong Hu

Journal Article

Zfyve16 regulates the proliferation of B-lymphoid cells

Xuemei Zhao, Donghe Li, Qingsong Qiu, Bo Jiao, Ruihong Zhang, Ping Liu, Ruibao Ren

Journal Article

Engineered Vasculature for Organ-on-a-Chip Systems

Abdellah Aazmi, Hongzhao Zhou, Yuting Li, Mengfei Yu, Xiaobin Xu, Yutong Wu, Liang Ma, Bin Zhang, Huayong Yang

Journal Article

A literature review of perishable medical resource management

Journal Article

Piezoelectric pump with flexible venous valves for active cell transmission

Journal Article

Review on the 3D Printing of Functional Structures for Medical Phantoms and Regenerated Tissue and Organ

Kan Wang, Chia-Che Ho, Chuck Zhang, Ben Wang

Journal Article

A novel intravenous general anesthetic--- emulsified isoflurane: from bench to bedside

Cheng Zhou, Jin Liu

Journal Article

State-of-the-art of intelligent minimally invasive surgical robots

Masakatsu G. Fujie, Bo Zhang

Journal Article

Organ function support in patients with coronavirus disease 2019: Tongji experience

Yong Li, Fan He, Ning Zhou, Jia Wei, Zeyang Ding, Luyun Wang, Peng Chen, Shuiming Guo, Binhao Zhang, Xiaoning Wan, Wei Zhu, on behalf of Multidisciplinary Team for COVID-19, Optical Valley Branch of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China

Journal Article

Determining “abnormal” levator hiatus distensibility using three-dimensional transperineal ultrasound in Chinese women

Chaoran Dou, Qin Li, Tao Ying, Yulin Yan, Xia Wang, Bing Hu

Journal Article

Legacies and health risks of heavy metals, polybrominated diphenyl ethers, and polychlorinated dibenzo-dioxins/furans at e-waste recycling sites in South China

Journal Article

Tissue Engineering： Leading Edge of Modern Bio-life Science

Zhang Disheng

Journal Article